Journal
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
Volume 32, Issue 2, Pages 409-414Publisher
WILEY
DOI: 10.1111/jgh.13491
Keywords
Barrett's esophagus (BE); esophageal adenocarcinoma (EAC); prospective cohort study
Categories
Funding
- Research Grant of Japan Gastroenterological Endoscopy Society
- Grants-in-Aid for Scientific Research [26460937] Funding Source: KAKEN
Ask authors/readers for more resources
Background and AimThe incidence of esophageal adenocarcinoma (EAC) in cases with long-segment Barrett's esophagus (BE) has not been investigated in Japan. The aim of this study is to investigate the incidence of EAC in Japanese cases with long-segment BE prospectively. MethodsThis is a multicenter prospective cohort study investigating the incidence rate of EAC in patients with BE with a length of at least 3cm. Study subjects received index esophagogastroduodenoscopy at the time of enrollment, and they were instructed to undergo yearly follow-up esophagogastroduodenoscopy. Patients in whom EAC was diagnosed in the endoscopic examinations underwent subsequent treatment, and their prognosis was observed. ResultsOf 215 enrolled patients, six (2.8%) were initially diagnosed with EAC at the enrollment. Among the remaining 209 patients, 132 received at least one follow-up esophagogastroduodenoscopy. In this follow-up, three EACs developed in 251 observed patient-years (incidence rate: 1.2% per year). Most of the EACs detected at the initial endoscopic examination (5/6, 83%) were already at advanced stages. Meanwhile, all the three lesions detected in the follow-up esophagogastroduodenoscopies were identified as early cancers and subjected to curative resection. ConclusionsThe incidence rate of EAC in Japanese cases with long-segment BE was calculated to be 1.2% in a year.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available