Journal
JOURNAL OF FOOD BIOCHEMISTRY
Volume 41, Issue 5, Pages -Publisher
WILEY
DOI: 10.1111/jfbc.12394
Keywords
immunomodulatory efficacy; Impatiens balsamina L; mast cell; proinflammatory cytokine; solar salt
Funding
- Solar Salt Research Center from Ministry of Oceans and Fisheries of Korea [20130290]
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Beauty-salt (BS, Mi-salt) is a type of food additive mainly used in Korea. It is composed of solar salt and Impatiens balsamina L. extracts. Here, the present study reports the immunomodulatory efficacy and underlying mechanisms of BS and its active components, ferulic acid (FA) and magnesium (Mg), on the human mast cell line HMC-1. BS significantly suppressed the production and mRNA expression of the proinflammatory cytokines, thymic stromal lymphopoietin (TSLP), interleukin (IL)-1 beta, IL-6, and IL-8 in activated HMC-1 cells without cytotoxicity. FA or Mg significantly decreased the production of TSLP and IL-1 beta but not IL-6 and IL-8. In activated mast cells, the pathways of caspase-1, nuclear factor (NF)-kappa B, and receptor-interacting protein 2 (RIP2) were blocked by treatment with BS, FA, or Mg. Furthermore, BS suppressed the activation of mitogen-activated protein (MAP) kinases. The present findings provide new scientific evidence that BS has good immunomodulatory efficacy by down-regulating caspase-1/NF-kappa B/RIP2/MAP kinase pathways.
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