Journal
PROCEEDINGS OF 2019 IEEE 7TH INTERNATIONAL CONFERENCE ON BIOINFORMATICS AND COMPUTATIONAL BIOLOGY (ICBCB 2019)
Volume -, Issue -, Pages 7-11Publisher
IEEE
DOI: 10.1109/icbcb.2019.8854647
Keywords
porcine enteric alphacoronavirus; genome assembly; phylogenetic evolution
Funding
- National Key Research and Development Program [2016YFD0500101]
- Suzhou Science and Technology Development Plan [SNG2018042]
- Teachers' Research Start-up Fund from Changshu Institute of Technology [KYZ2018009Q]
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Severe diarrhea in suckling piglets occurred in southern China in 2017 and a new porcine coronavirus, named as porcine enteric alphacoronavirus (PEAV), was identified. Here we reported a detailed process to sequence, assemble and analyze the whole genome of PEAV. GDS04 has 87% amino acid identity comparing to the S proteins of the HKU2 strains without recombination, and their receptor-binding domains in S protein differ at 20 amino acids, suggesting that GDS04 could be a new mutant virus from bat-like CoVs and responsible for the most recent diarrhea endemic in pig herds in southern China.
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