Journal
JOURNAL OF EXPERIMENTAL MEDICINE
Volume 215, Issue 1, Pages 249-262Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.20170832
Keywords
-
Categories
Funding
- Center for Cancer Research at the National Cancer Institute
- NATIONAL CANCER INSTITUTE [ZIABC011633] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI054977] Funding Source: NIH RePORTER
Ask authors/readers for more resources
Early innate lymphoid progenitors (EILPs) have recently been identified in mouse adult bone marrow as a multipotential progenitor population specified toward innate lymphoid cell (ILC) lineages, but their relationship with other described ILC progenitors is still unclear. In this study, we examine the progenitor-successor relationships between EILPs, all-lymphoid progenitors (ALPs), and ILC precursors (ILCps). Functional, bioinformatic, phenotypical, and genetic approaches collectively establish EILPs as an intermediate progenitor between ALPs and ILCps. Our work additionally provides new candidate regulators of ILC development and clearly defines the stage of requirement of transcription factors key for early ILC development.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available