Journal
JOURNAL OF EXPERIMENTAL MEDICINE
Volume 214, Issue 4, Pages 1111-1128Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.20161382
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Funding
- National Institutes for Health Research (NIHR) Cambridge Biomedical Research Centre
- Wellcome Trust/CIMR Next Generation Fellowship
- National Institute for Health Research (NIHR) Clinical Lectureship
- Starter Grant for Clinical Lecturers (Academy of Medical Sciences)
- Medical Research Council [MR/L019027]
- NIHR
- Wellcome Trust [098051, 079895]
- Wellcome Intermediate Clinical Fellowship [105920/2/14/2]
- MRC [MR/L019027/1] Funding Source: UKRI
- Medical Research Council [MR/L019027/1] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0514-10109] Funding Source: researchfish
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The phagocyte respiratory burst is crucial for innate immunity. The transfer of electrons to oxygen is mediated by a membrane-bound heterodimer, comprising gp91phox and p22phox subunits. Deficiency of either subunit leads to severe immunodeficiency. We describe Eros (essential for reactive oxygen species), a protein encoded by the previously undefined mouse gene bc017643, and show that it is essential for host defense via the phagocyte NAPDH oxidase. Eros is required for expression of the NADPH oxidase components, gp91phox and p22phox. Consequently, Eros-deficient mice quickly succumb to infection. Eros also contributes to the formation of neutrophil extracellular traps (NETS) and impacts on the immune response to melanoma metastases. Eros is an ortholog of the plant protein Ycf4, which is necessary for expression of proteins of the photosynthetic photosystem 1 complex, itself also an NAD.PH oxio-reductase. We thus describe the key role of the previously uncharacterized protein Eros in host defense.
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