More than just an intermediate: hydrogen sulfide signalling in plants

Hydrogen sulfide (H2S) has come a long way from air pollutant, to intermediate in sulfur assimilation, to signalling molecule. Using a proteomic approach, Aroca et al. (2017) investigated post-translational modifications of cysteine residues (protein persulfidation) controlled by H2S to show that at least 5% of the entire proteome encoded by the Arabidopsis genome is persulfidated and, completing the journey, that H2S is indeed a signalling molecule in plants.