Journal
JOURNAL OF EXPERIMENTAL BIOLOGY
Volume 220, Issue 1, Pages 6-17Publisher
COMPANY OF BIOLOGISTS LTD
DOI: 10.1242/jeb.148148
Keywords
Red Queen; Antagonism; Mutualism; Toxin-antitoxin; Meiosis; Mitochondria; Wolbachia; Host-pathogen
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Funding
- Howard Hughes Medical Institute postdoctoral fellowship of the Helen Hay Whitney Foundation
- National Institute of General Medical Sciences at the National Institutes of Health [K99/R00, 1K99GM112941, R01GM074108]
- Mathers Foundation
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [P50GM107632, K99GM112941, R00GM112941, R01GM074108] Funding Source: NIH RePORTER
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Selfishness is pervasive and manifests at all scales of biology, from societies, to individuals, to genetic elements within a genome. The relentless struggle to seek evolutionary advantages drives perpetual cycles of adaptation and counter-adaptation, commonly referred to as Red Queen interactions. In this review, we explore insights gleaned from molecular and genetic studies of such genetic conflicts, both extrinsic (between genomes) and intrinsic (within genomes or cells). We argue that many different characteristics of selfish genetic elements can be distilled into two types of advantages: an over-replication advantage (e.g. mobile genetic elements in genomes) and a transmission distortion advantage (e.g. meiotic drivers in populations). These two general categories may help classify disparate types of selfish genetic elements.
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