Journal
Publisher
SCITEPRESS
DOI: 10.5220/0007363900480059
Keywords
Generative Adversarial Networks; Deep Learning; MRI; Data Augmentation; ADNI; Alzheimer's Disease
Funding
- Alzheimer's Disease Neuroimaging Initiative (ADNI) (National Institutes of Health) [U01 AG024904]
- DOD ADNI (Department of Defense) [W81XWH-12-2-0012]
- National Institute on Aging
- National Institute of Biomedical Imaging and Bioengineering
- AbbVie
- Alzheimer's Association
- Alzheimer's Drug Discovery Foundation
- Araclon Biotech
- BioClinica, Inc.
- Biogen
- Bristol-Myers Squibb Company
- CereSpir, Inc.
- Cogstate
- Eisai Inc.
- Elan Pharmaceuticals, Inc.
- Eli Lilly and Company
- EuroImmun
- F. Hoffmann-La Roche Ltd and its affiliated company Genentech, Inc.
- Fujirebio
- GE Healthcare
- IXICO Ltd.
- Janssen Alzheimer Immunotherapy Research & Development, LLC.
- Johnson & Johnson Pharmaceutical Research & Development LLC.
- Lumosity
- Lundbeck
- Merck Co., Inc.
- Meso Scale Diagnostics, LLC.
- NeuroRx Research
- Neurotrack Technologies
- Novartis Pharmaceuticals Corporation
- Pfizer Inc.
- Piramal Imaging
- Servier
- Takeda Pharmaceutical Company
- Transition Therapeutics
- The Canadian Institutes of Health Research
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This paper presents a new methodology for data augmentation through the use of Generative Adversarial Networks. Traditional augmentation strategies are severely limited, especially in tasks where the images follow strict standards, as is the case in medical datasets. Experiments conducted on the ADNI dataset prove that augmentation through GANs outperforms traditional methods by a large margin, based both on the validation accuracy and the models' generalization capability on a holdout test set. Although traditional data augmentation did not seem to aid the classification process in any way, by adding GAN-based augmentation an increase of 11.68% in accuracy was achieved. Furthermore, by combining traditional with GAN-based augmentation schemes, even higher accuracies can be reached.
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