Journal
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
Volume 32, Issue 1, Pages 917-919Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14756366.2017.1344235
Keywords
Database; beta-lactamase; antibiotic resistance; hydrolytic profile; mutant
Funding
- Laboratory of Excellence in Research on Medication and Innovative Therapeutics (LERMIT) [ANR-10-LABX-33]
- JPIAMR [ANR-14-JAMR-0002]
- Region Ile-de-France (DIM Malinf)
Ask authors/readers for more resources
Beta-Lactamase Database (BLDB) is a comprehensive, manually curated public resource providing up-to-date structural and functional information focused on this superfamily of enzymes with a great impact on antibiotic resistance. All the enzymes reported and characterised in the literature are presented according to the class (A, B, C and D), family and subfamily to which they belong. All three-dimensional structures of beta-lactamases present in the Protein Data Bank are also shown. The characterisation of representative mutants and hydrolytic profiles (kinetics) completes the picture and altogether these four elements constitute the essential foundation for a better understanding of the structure-function relationship within this enzymes family. BLDB can be queried using different protein-and nucleotide-based BLAST searches, which represents a key feature of particular importance in the context of the surveillance of the evolution of the antibiotic resistance. BLDB is available online at http://bldb.eu without any registration and supports all modern browsers.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available