Journal
JOURNAL OF ENVIRONMENTAL PATHOLOGY TOXICOLOGY AND ONCOLOGY
Volume 36, Issue 3, Pages 217-228Publisher
BEGELL HOUSE INC
DOI: 10.1615/JEnvironPatholToxicolOncol.2017020213
Keywords
cutaneous melanoma; melanomagenesis; solar radiation; UVA; DNA damage; CPD; oxidative stress; DNA repair
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Funding
- National Natural Science Foundation of China [11364040]
- Tibet University
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Cutaneous melanoma is a deadly skin cancer, resulting from malignant transformation of melanocytes. Long-wave ultraviolet radiation (315-400 nm) is able to damage DNA, cause mutations, and induce melanoma. However, the exact mechanisms of UVA-induced cutaneous melanoma remain a matter of debate. In this review, we give a brief characterization of the most important elements in the photobiology of UVA in melanomagenesis.
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