Journal
TRENDS IN CANCER
Volume 5, Issue 1, Pages 7-10Publisher
CELL PRESS
DOI: 10.1016/j.trecan.2018.10.006
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Funding
- National Science Center, Poland [2012/07/B/NZ7/01178, 2013/09/B/NZ5/02794, 2013/11/B/NZ1/00091, 2016/23/B/NZ5/00573]
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High-fat diet is associated with elevated plasma homocysteine (Hcy), and both are linked to cancer. Although Hcy is not a coded amino acid, proteins do carry Hcy modifications formed viaa pathwayinvolving methionyl-tRNA synthetase-catalyzed metabolic conversion of Hcy to Hcy-thiolactone. Hcy-thiolactone then chemically reacts with protein lysine residues, affording KHcy-protein. Recently, Wang et al. [1] (Cell Rep. 2018;25:398-412.e6) showed that this pathway promotes colorectal cancer by impairing DNA damage repair.
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