Journal
JOURNAL OF ENDOCRINOLOGY
Volume 236, Issue 1, Pages R69-R91Publisher
BIOSCIENTIFICA LTD
DOI: 10.1530/JOE-17-0361
Keywords
glucocorticoids; growth; mouse; murine; osteoporosis; skeletal development
Categories
Funding
- Medical Research Council (MRC) [MR/N020588/1]
- Chief Scientist Office (CSO) [CAF/DMD/14/01]
- Swedish Research Council [2015-02406]
- ESPE Research Fellowship
- Novo Nordisk A/S
- Swedish Research Council
- Swedish Society for Medical Research
- Swedish Childhood Cancer Foundation
- Sallskapet Barnavard
- HKH Kronprinsessan Lovisas Forening for Barnasjukvard/Stiftelsen Axel Tielmans Minnesfond
- Biotechnology and Biological Sciences Research Council (BBSRC) for Institute Strategic Programme Grant Funding [BB/J004316/1, BBS/E/D/20221657]
- Biotechnology and Biological Sciences Research Council [BBS/E/D/10002071] Funding Source: researchfish
- Medical Research Council [MR/N020588/1, MR/N003403/1] Funding Source: researchfish
- Chief Scientist Office [CAF/DMD/14/01] Funding Source: researchfish
- Muscular Dystrophy UK [MC3/1083] Funding Source: researchfish
- BBSRC [BBS/E/D/10002071] Funding Source: UKRI
- MRC [MR/N020588/1, MR/N003403/1] Funding Source: UKRI
Ask authors/readers for more resources
Glucocorticoids (GCs) are effective for the treatment of many chronic conditions, but their use is associated with frequent and wide-ranging adverse effects including osteoporosis and growth retardation. The mechanisms that underlie the undesirable effects of GCs on skeletal development are unclear, and there is no proven effective treatment to combat them. An in vivo model that investigates the development and progression of GC-induced changes in bone is, therefore, important and a well-haracterized pre-clinical model is vital for the evaluation of new interventions. Currently, there is no established animal model to investigate GC effects on skeletal development and there are pros and cons to consider with the different protocols used to induce osteoporosis and growth retardation. This review will summarize the literature and highlight the models and techniques employed in experimental studies to date.
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