Journal
JOURNAL OF ENDOCRINOLOGY
Volume 234, Issue 1, Pages R67-R79Publisher
BIOSCIENTIFICA LTD
DOI: 10.1530/JOE-17-0147
Keywords
marrow adipose tissue; metabolism; bone; osteoblast; pancreas
Categories
Funding
- Medical Research Council [MR/M021394/1]
- Biotechnology and Biological Sciences Research Council (BBSRC) [BB/J004316/1, BBS/E/D/20221657]
- Wellcome Trust [100981/z/13/z]
- BBSRC [BBS/E/D/20221657, BBS/E/D/10002071] Funding Source: UKRI
- MRC [MR/M021394/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BBS/E/D/20221657, BBS/E/D/10002071] Funding Source: researchfish
- Medical Research Council [MR/M021394/1] Funding Source: researchfish
- Wellcome Trust [100981/Z/13/Z] Funding Source: researchfish
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Throughout the last decade, significant developments in cellular, molecular and mouse models have revealed major endocrine functions of the skeleton. More recent studies have evolved the interplay between bone-specific hormones, the skeleton, marrow adipose tissue, muscle and the brain. This review focuses on literature from the last decade, addressing the endocrine regulation of global energy metabolism via the skeleton. In addition, we will highlight several recent studies that further our knowledge of new endocrine functions of some organs; explore remaining unanswered questions; and, finally, we will discuss future directions for this more complex era of bone biology research.
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