Journal
JOURNAL OF DIABETES AND ITS COMPLICATIONS
Volume 31, Issue 3, Pages 599-604Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jdiacomp.2016.11.006
Keywords
Fetuin-a; Peripheral arterial disease; Lower extremity arterial calcification; Ankle-brachial index; Diabetes mellitus
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Funding
- Hellenic National Diabetes Center, Athens, Greece [1/23-2-2007]
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Aims: Fetuin-A is a hepatic glycoprotein that is involved in insulin resistance and atherosclerosis. Herein we examined the association of plasma fetuin-A levels with peripheral arterial disease (PAD) in patients with type 2 diabetes mellitus (T2DM). Material and Methods: A total of 71 patients with T2DM and 57 non-diabetic individuals were recruited. Diagnosis of PAD was based on the absence of triphasic waveform at pedal arteries, while ankle-brachial index (ABI) was calculated. Radiographs of both feet and ankles were taken for the assessment of lower extremity arterial calcification (LEAC). Plasma fetuin-A levels were measured using ELISA. Results: Patients with T2DM had higher fetuin-A levels than non-diabetic participants. Participants with diabetes and PAD had lower fetuin-A levels than non-PAD diabetic patients. In subjects with T2DM fetuin-A levels were associated with ABI. Multivariate analysis demonstrated that in patients with T2DM the odds of PAD increased with long diabetes duration, smoking, presence of arterial hypertension and dyslipidemia, as well as with lower fetuin-A levels. A trend towards higher fetuin-A levels in subjects with less severe LEAC was found. Conclusion: Plasma fetuin-A levels are lower its patients with T2DM anti PAD and are associated with PAD. irrespective of traditional cardiovascular risk factors. Moreover, fetuin-A may be involved in arterial calcification. (C) 2017 Elsevier Inc. All rights reserved.
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