Journal
JOURNAL OF DERMATOLOGY
Volume 45, Issue 3, Pages 252-263Publisher
WILEY
DOI: 10.1111/1346-8138.14112
Keywords
immune system; keratinocytes; mouse model; psoriasis; signal transducer and activator of transcription 3
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Funding
- Grants-in-Aid for Scientific Research [15K09769, 16K10162] Funding Source: KAKEN
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Psoriasis is an inflammatory skin disorder that includes dynamic interactions between the immune system and skin and is clinically characterized by keratinocyte proliferation and distinct inflammatory cell infiltrates. Cross-talk between keratinocytes and immunocytes is essential for the development of psoriasis given that it mediates the production of cytokines, chemokines and growth factors. To resolve the pathogenesis of psoriasis, numerous experimental animal models have been generated. In this review, we discuss recent findings from mouse models, their relevancy to psoriasis and use, including the discovery of new therapies.
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