Journal
JOURNAL OF DERMATOLOGICAL TREATMENT
Volume 28, Issue 8, Pages 726-730Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/09546634.2017.1329498
Keywords
Endothelial cell activation; atherosclerosis; psoriasis; biologic therapy; biomarkers
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Funding
- Abbvie Inc [ACA-SPAI-10-21]
- Sara Borrell postdoctoral fellowship from the Instituto de Salud Carlos III (ISCIII), Spain [CD15/00095]
- Miguel Servet type I program from the ISCIII, Spain [CP16/00033]
- RETICS Program (RIER) from the ISCIII, Spain [RD12/0009/0013, RD16/0012/0009]
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Purpose: Psoriasis patients have high risk of atherosclerosis, characterized by endothelial dysfunction. We aimed to study the association of the endothelial activation biomarkers monocyte chemoattractant protein 1 (MCP-1), soluble (s) E-selectin and P-selectin with disease activity and severity in psoriasis patients treated with anti-TNF-alpha therapy. Also, to evaluate the relationship of metabolic syndrome features with these biomarkers and the effect of anti-TNF-alpha therapy on these molecules. Methods: Twenty-nine consecutive non-diabetic patients with moderate-to-severe psoriasis who underwent 6 months of anti-TNF-alpha-adalimumab therapy were studied. Metabolic and clinical evaluation was performed prior to anti-TNF-alpha treatment (time 0) and 6 months later. MCP-1, sE-selectin and sP-selectin serum levels were determined by ELISA. Results: Dyslipidemic and obese patients showed higher MCP-1 levels at month 6 from the onset of anti-TNF-alpha therapy (p =.05 and.01, respectively). sE-selectin positively correlated with pro-inflammatory molecules such as asymmetric dimethylarginine, sP-selectin and resistin at baseline and month 6 (p<.05). sE-selectin levels significantly reduced after 6 months of therapy (p = .0006). Conclusions: Metabolic syndrome features are associated with endothelial activation in patients with moderate-to-severe psoriasis. Adalimumab therapy led to a reduction in sE-selectin levels, supporting the beneficial effect of anti-TNF-alpha therapy on mechanisms associated with the development of atherosclerosis in psoriasis.
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