Journal
JOURNAL OF DENTAL RESEARCH
Volume 96, Issue 7, Pages 725-732Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/0022034517706678
Keywords
nanofibers; nanoparticles; nanotubes; nanosheets; oral and maxillofacial regions; tissue regeneration
Categories
Funding
- National Natural Science Foundation of China [81671031, 81402860]
- Sichuan Province Youth Science and Technology Innovation Team [2014TD0001]
- Funds of Sichuan University [2016SCU11043]
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Tissue engineering shows great potential as a future treatment for the craniofacial and dental defects caused by trauma, tumor, and other diseases. Due to the biomimetic features and excellent physiochemical properties, nanomaterials are of vital importance in promoting cell growth and stimulating tissue regeneration in tissue engineering. For craniofacial and dental tissue engineering, the frequently used nanomaterials include nanoparticles, nanofibers, nanotubes, and nanosheets. Nanofibers are attractive for cell invasion and proliferation because of their resemblance to extracellular matrix and the presence of large pores, and they have been used as scaffolds in bone, cartilage, and tooth regeneration. Nanotubes and nanoparticles improve the mechanical and chemical properties of scaffold, increase cell attachment and migration, and facilitate tissue regeneration. In addition, nanofibers and nanoparticles are also used as a delivery system to carry the bioactive agent in bone and tooth regeneration, have better control of the release speed of agent upon degradation of the matrix, and promote tissue regeneration. Although applications of nanomaterials in tissue engineering remain in their infancy with numerous challenges to face, the current results indicate that nanomaterials have massive potential in craniofacial and dental tissue engineering.
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