Journal
JOURNAL OF CONTROLLED RELEASE
Volume 258, Issue -, Pages 226-253Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jconrel.2017.04.043
Keywords
Nanomedicine; Smart chemistry; Nanocarrier; Drug delivery
Funding
- National Research Foundation of Korea (NRF) - Korea government (MSIP) [2015R1A2A2A01004118, 2015R1A2A2A04004806]
- Medical Research Center Program through the NRF - MSIP [2015R1A5A2009124]
- National Research Foundation of Korea [22A20154413174, 2015R1A2A2A04004806, 2015R1A2A2A01004118, 2015R1A5A2009124] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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This review focuses on the smart chemistry that has been utilized in developing polymer-based drug delivery systems over the past 10 years. We provide a comprehensive overview of the different functional moieties and reducible linkages exploited in these systems, and outline their design, synthesis, and application from a therapeutic efficacy viewpoint. Furthermore, we highlight the next generation nanomedicine strategies based on this novel chemistry.
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