Journal
KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY
Volume 24, Issue 1, Pages 121-126Publisher
KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY
DOI: 10.4196/kjpp.2020.24.1.121
Keywords
Drug addiction; Glycogen synthase kinase; Nucleus accumbens; Protein kinase B; Signal transduction
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Funding
- Faculty Research Grant from Yonsei University College of Medicine [6-2013-0148]
- National Research Foundation of Korea (NRF) [2018025230, 2019R1A2C1011262]
- Korea government (MSIT)
- National Research Foundation of Korea [2019R1A2C1011262] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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The ezrin-radixin-moesin (ERM) proteins are a family of membrane-assodated proteins known to play roles in cell-shape determination as well as in signaling pathways. We have previously shown that amphetamine decreases phosphorylation levels of these proteins in the nucleus accumbens (NAcc), an important neuronal substrate mediating rewarding effects of drugs of abuse. In the present study, we further examined what molecular pathways may be involved in this process. By direct microinjection of LY294002, a PI3 kinase inhibitor, or of S9 peptide, a proposed GSK3 beta activator, into the NAcc core, we found that phosphorylation levels of ERM as well as of GSK3 beta in this site are simultaneously decreased. These results indicate that ERM proteins are under the regulation of Akt-GSK3 beta signaling pathway in the NAcc core. The present findings have a significant implication to a novel signal pathway possibly leading to structural plasticity in relation with drug addiction.
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