Journal
HEAD & NECK PATHOLOGY
Volume 14, Issue 4, Pages 1094-1104Publisher
SPRINGER
DOI: 10.1007/s12105-019-01120-3
Keywords
Adenoid cystic carcinoma; Dedifferentiation; high-grade transformation; Sarcomatoid differentiation
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Adenoid cystic carcinoma (AdCC) comprises of less than 1% of all head and neck cancers and less than 10% of all salivary gland neoplasms. Dedifferentiation/high-grade transformation (HGT) in AdCC is a rare but well known phenomenon which is associated with aggressive clinical behaviour and poor prognosis. We herein report the clinical, cytologic, histologic and immunohistochemical findings of a left submandibular gland AdCC with transformation to high grade carcinomatous and probable dedifferentiation to sarcomatoid component, occurring in a 64 year old male patient. To the author's best knowledge, this is the first case report of such dual transformation occurring in adenoid cystic carcinoma.
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