Journal
RESPIRATORY RESEARCH
Volume 21, Issue 1, Pages -Publisher
BMC
DOI: 10.1186/s12931-020-1279-4
Keywords
COPD; Eosinophil; Airway inflammation
Categories
Funding
- MRC (United Kingdom)
- NIHR Manchester BRC
- MRC [G0800570, G1001365, G0601369] Funding Source: UKRI
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Blood eosinophils are a predictive biomarker of inhaled corticosteroid response in chronic obstructive pulmonary disease (COPD). We investigated blood eosinophil stability over 1 year using the Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2019 thresholds of < 100, 100- < 300 and >= 300 eosinophils/mu L in 225 patients from the COPDMAP cohort. Blood eosinophils showed good stability (rho: 0.71, p < 0.001, ICC 0.84), and 69.3% of patients remained in the same eosinophil category at 1 year. 85.3% of patients with eosinophils < 100 cells/mu L had stable counts. The majority of blood eosinophil counts remain stable over 1 year using the GOLD 2019 thresholds.
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