Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 18, Issue 2, Pages 225-229Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9ob02430a
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Funding
- Natural Science Foundation of China [21801152, 21572110]
- Natural Science Foundation of Shandong Province [ZR2019BB005, ZR2019MB010]
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The general protocol for the synthesis of isoxazolidine-fused isoquinolin-1(2H)-ones was established with the help of bench stable hypervalent iodine reagent PIDA. Polycyclic six-, seven- and eight-membered N-heterocycles can be rapidly synthesized from available amides under metal-free conditions within 1 min at room temperature through C-H/N-H functionalization. Moreover, the protocol has the merits of broad substrate scope, atom economy and operational simplicity.
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