Journal
ACS APPLIED BIO MATERIALS
Volume 3, Issue 1, Pages 377-384Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsabm.9b00863
Keywords
sandwich-type electrochemical immunosensor; CuPtRh CNBs/NH2-Ti3C2; trimetallic nanocatalysts; MXene; cardiac troponin I
Funding
- National Natural Science Foundation of China [21405095, 21575079, 21671121, 21576158]
- Natural Science Foundation of Shandong Province [ZR2018MB008, ZR2018MB012, ZR2017JL014]
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An early diagnosis of cardiovascular disease is of great importance to patients. Herein, a sandwich-type immunosensor for the detection of cardiac troponin I (cTnI) is prepared by using gold nanoparticles (Au NPs) and a composite (CuPtRh CNBs/NH2-Ti3C2) of trimetallic hollow CuPtRh cubic nanobox (CNB)-embedded few-layer ultrathin ammoniated MXene (NH2-Ti3C2). The embedding of the CuPtRh CNBs into NH2-Ti3C2 successfully prevents the restacking of NH2-Ti3C2 and offers more active sites for catalytic H2O2 reduction, which can effectively increase the current signal of the immunosensor. The designed sandwich-type electrochemical immunosensor for detection cTnI has a detection range of 25 fg mL(-1) to 100 ng mL(-1), and the detection limit is 8.3 fg mL(-1) (S/ N = 3). Moreover, the immunosensor also demonstrates high sensitivity, acceptable reproducibility, and good stability. More importantly, the designed system offers a direction for early clinical testing of cardiovascular and cerebrovascular diseases.
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