Journal
ACS APPLIED BIO MATERIALS
Volume 3, Issue 1, Pages 2-9Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsabm.9b00558
Keywords
peptide nucleic acid; porphyrin; self-assembly; nanodrug; photodynamic therapy
Funding
- National Natural Science Foundation of China [21773248, 51861145304]
- Innovation Research Community Science Fund [21821005]
- Key Research Program of Frontier Sciences of the Chinese Academy of Sciences (CAS) [QYZDB-SSW-JSC034]
- European Union
- Greek national funds through the Operational Program Competitiveness, Entrepreneurship and Innovation, under the call RESEARCH CREATE INNOVATE [T1EDK-01504]
- General Secretariat for Research and Technology (GSRT)
- Hellenic Foundation for Research and Innovation (HFRI) [508]
- European Commission [229927]
- Special Research Account of the University of Crete
- Chinese Academy of Sciences President's International Fellowship Initiative [2018VEA0005]
Ask authors/readers for more resources
Two hybrid materials were designed by conjugating peptide nucleic acids (PNAs) to porphyrin or boron-dipyrromethene, generating PNA-porphyrin (PNA-TPP) and PNA-BODIPY (PNA-BDP) conjugates, respectively. Because of the combination of the supramolecular characteristics of PNAs and photosensitizers, the two hybrid conjugates readily self-assemble in aqueous solutions and produce well-defined nanoparticles with uniform particle sizes. The resulting two kinds of nanoparticles show good stability in biological solutions and upon dilution. Importantly, the nanoparticles can efficiently interact with cancer cells and the internalized nanoparticles are mainly distributed in the cytoplasm without discernible cytotoxicity in the dark, enabling them to be applied as photodynamic nanoagents for selective killing cells. Hence, self-assembly of PNA-photosensitizer conjugates may hold promise for advancing the rational design and construction of photodynamic nanoagents for cancer therapy.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available