Journal
CHEMICAL COMMUNICATIONS
Volume 56, Issue 4, Pages 583-586Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9cc08894f
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Funding
- National Natural Science Foundation of China [81971677]
- Natural Science Foundation of Jiangsu Province [BK20191320]
- 62th China postdoctoral science foundation [1600010008]
- Double First-rate Foundation of China Pharmaceutical University [CPU2018GY20]
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In this report, we demonstrate a V-shaped NIRF probe PTO-29, which can monitor A beta oligomers with high selectivity. PTO-29 was designed and showed significant response to A beta oligomers in the fluorescence spectral tests and good properties. In vivo imaging results indicate that 4 month APP/PS1 AD mice have higher signals in the brain than age-matched wild type mice.
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