Journal
CHEMICAL SCIENCE
Volume 11, Issue 4, Pages 1026-1031Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9sc05132e
Keywords
-
Categories
Funding
- National Natural Science Foundation of China [21732002, 21672117]
- PhD Candidate Research Innovation Fund of the College of Chemistry, Nankai University
Ask authors/readers for more resources
Formyl-selective deuteration of aldehydes is of high interest for labeling purposes and for optimizing properties of drug candidates. Herein, we report a mild general method for formyl-selective deuterium labeling of aldehydes with D2O, an inexpensive deuterium source, via a synergistic combination of light-driven, polyoxometalate-facilitated hydrogen atom transfer and thiol catalysis. This highly efficient, scalable reaction showed excellent deuterium incorporation, a broad substrate scope, and excellent functional group tolerance and selectivity and is therefore a practical method for late-stage modification of synthetic intermediates in medicinal chemistry and for generating libraries of deuterated compounds.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available