Journal
SOFT MATTER
Volume 16, Issue 4, Pages 1002-1010Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9sm01833f
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Funding
- Occigen supercomputer [A0010710123]
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We report results from full atomistic molecular dynamics simulations on the properties of biomimetic nanopores. This latter result was obtained through the direct insertion of an alpha-hemolysin protein inside a hydrophobic solid-state nanopore. Upon translocation of different DNA strands, we demonstrate here that the theoretical system presents the same discrimination properties as the experimental one obtained previously. This opens an interesting way to promote the stability of a specific protein inside a solid nanopore to develop further biomimetic applications for DNA or protein sequencing.
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