Journal
ADVANCED THERAPEUTICS
Volume 3, Issue 2, Pages -Publisher
WILEY
DOI: 10.1002/adtp.201900136
Keywords
bioconjugation; biomaterials; cancer; liposomes; micelles; nanoparticles
Categories
Funding
- National Institutes of Health [1R01GM113166]
- Faculty Startup fund University of Nebraska Medical Center
Ask authors/readers for more resources
Nanocarriers have the capability to deliver a variety of drugs to disease sites. Different biological barriers prevent the successful delivery of nanoformulations to target sites, thereby limiting effective therapeutic response. Although numerous efforts have been made to design novel nanocarriers by incorporating various functionalities to get better therapies, most strategies have failed to translate drug delivery systems to the clinic. Impediments such as the incapability to hold drugs stably in nanocarriers during circulation, non-specific distribution, and inadequate delivery of therapeutic agents to target sites due to complex tumor microenvironment remain a challenge. Herein, different organic polymer and lipid-based nanocarriers and their encouraging therapeutic effectiveness to treat cancer are discussed. Recent development in multifunctional and stimuli sensitive nanocarriers is also highlighted. Finally, the challenges and innovative strategies to overcome various obstacles and limitations for their successful translation into the clinic are discussed.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available