Journal
CHEMICAL COMMUNICATIONS
Volume 56, Issue 5, Pages 762-765Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9cc09357e
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Funding
- National Natural Science Foundation of China [21674080]
- Leading Talents Program of the Tianjin Educational Committee
- Key Program of Tianjin Municipal Natural Science Foundation [18JCZDJC37700]
- Training Project of Innovation Team of Colleges and Universities in Tianjin [TD13-5020]
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A multifunctional photodynamic therapy (PDT) nanoplatform, characterized by red-shifted absorption and emission, was fabricated using an UiO-66-based metal-organic framework (MOF), a biscyclometalated iridium(iii) complex, and a pH/ROS-responsive polycationic polymer. Noticeably, this promising nanoplatform exhibited good biocompatibility in the dark and produced abundant ROS upon light irradiation, which could achieve apparent endo/lysosome escape and kill cancer cells effectively.
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