Journal
CHEMICAL COMMUNICATIONS
Volume 56, Issue 5, Pages 695-698Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9cc09389c
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Funding
- National Natural Science Foundation of China [31671923]
- Shanghai Pujiang Program [18PJD016]
- Ministry of Education, Kingdom of Saudi Arabia [PCSED-003-18]
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In this work, a hydrazone chemistry assisted DNAzyme has been designed and constructed. The introduction of hydrazone chemistry increases the versatility of DNAzymes. With superior catalytic capability, the hydrazone chemistry assisted DNAzyme has been successfully applied for the analysis of double targets. Taking 5-hydroxymethylfurfural (HMF) and lipopolysaccharide (LPS) as samples, the hydrazone chemistry assisted DNAzyme can be used for the detection of different combinations of targets. Moreover, because hydrazone chemistry is popular in nature, this work may also provide a new insight for the development of DNAzymes and their multifunctionality.
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