Journal
DERMATOLOGICA SINICA
Volume 33, Issue 2, Pages 64-69Publisher
ELSEVIER TAIWAN
DOI: 10.1016/j.dsi.2015.04.010
Keywords
epidermal barrier; Mouse model; psoriasis; Skin inflammation
Categories
Funding
- Ministry of Education, Culture, Sports, Science and Technology of Japan [21591436, 21591467, 21591656]
- Ministry of Health, Labour, and Welfare of Japan [H23-028]
- Center of Biomembrane Functions Controlling Biological Systems of the Kochi University Research Center Project
- Grants-in-Aid for Scientific Research [21591436, 21591656, 21591467] Funding Source: KAKEN
Ask authors/readers for more resources
Skin is equipped with a barrier function, in particular, to prevent invasion of pathogens. Skin barrier is composed of a mechanical barrier, a permeability barrier, and innate and adaptive immunity barriers. Psoriasis is an inflammatory skin disease, which develops through the interaction of epidermal keratinocytes and immune cells, although its pathoetiology has not been fully understood. Recent studies revealed that defects in epidermal barrier-related genes were associated with a risk of psoriasis. Indeed, psoriasis is characterized by compromised barrier function, similar to atopic dermatitis (AD), in which mutations of the filaggrin gene play a role. However, it remains to be determined whether epidermal barrier disruption leads to an altered inflammatory/immunological response in psoriasis. In this review, I demonstrate evidence, in human psoriasis as well as mouse models, showing that barrier insult contributes to psoriasis development through alteration of the innate and adaptive immunity. Copyright (C) 2015, Taiwanese Dermatological Association. Published by Elsevier Taiwan LLC. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available