Journal
JOURNAL OF COLLOID AND INTERFACE SCIENCE
Volume 505, Issue -, Pages 1193-1201Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.jcis.2017.07.006
Keywords
Drug analysis; Nimorazole; Anti-cancer drug; Biosensor; Electrochemical biosensor; Modified electrode; Transition metal oxides
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Funding
- International Scientific Partnership Program ISPP at King Saud University
- national science council and ministry of science and technology, Taiwan (ROC)
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We described a three-dimensional Mn3O4 microcubes (3D Mn3O4MCs) synthesised via a facile hydrothermal route for the determination of nimorazole (NMZ), an important drug that used in the treatment of head and neck cancer. The 3D-Mn3O4 MCs possess large active area and high conductivity, and 3D-Mn3O4 MCs film modified screen-printed carbon electrode (3D-Mn3O4MCs/SPCE) was fabricated which displayed excellent electrocatalytic ability towards NMZ. Under optimised working conditions, the modified electrode responded linearly to NMZ in the 0.025-8060 mu M concentration range and the detection limit was 6 nM. A rapid, sensitive, selective, reproducible, and durable sensor was described. The practical feasibility of the sensor was demonstrated in human serum and NMZ tablet samples. The obtained results revealed the potential real-time applicability of the sensing device in biological analysis and pharmaceutical formulations. (C) 2017 Elsevier Inc. All rights reserved.
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