Journal
JOURNAL OF CLUSTER SCIENCE
Volume 28, Issue 5, Pages 2857-2872Publisher
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10876-017-1263-4
Keywords
Dengue; Microbial pathogen; Drug resistance; Nanosynthesis; XRD and TEM
Categories
Funding
- UGC [F1-17.1/RGNF-2012-13-SC-TAM-23853]
- Department of Biotechnology (DBT), New Delhi, India [BT/PR7903/AAquote/3/638/2013]
- Department of Science and Technology (DST), New Delhi, India [IF140145]
- Deanship of Scientific Research at King Saud University [RG-1438-091]
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The green synthesis of pesticides and antibiotics is gaining increasing importance nowadays. We fabricated Euphorbia rothiana-capped Ag nanoparticles (Er-AgNPs), testing their antibiofilm and growth inhibition potential on various microbial pathogens. We evaluated the toxicity of E. rothiana-capped Ag nanoparticles on larvae of the Zika virus vector Aedes aegypti, shedding light on histological changes post-exposure to the plant leaf extract and Er-AgNPs. Nanoparticles were characterized by UV-Vis, and FTIR spectroscopy, XRD and TEM. Light microscopy showed the greatest inhibition of biofilm formation in Gram positive and Gram-negative bacteria post-treatment with E. rothiana-capped Ag nanoparticles at 75 mu g/ml. Confocal microscopy confirmed the biofilm interruption and disintegration post-treatment with nanoparticles at 75 mu g/ml. E. rothiana extract and Er-AgNPs showed 100% larvicidal activity on A.aegypti at 50 and 8 mg/L, respectively. AgNO3 led to 100% mortality of A. aegypti larvae at 40 mg/L after 48 h. Stereomicroscopic and histopathological analysis reported tissue damages and loss of cuticular parts in mosquito larvae.
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