Journal
JOURNAL OF CLUSTER SCIENCE
Volume 28, Issue 3, Pages 1667-1684Publisher
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10876-017-1180-6
Keywords
Chloroquine sensitive strain; Green nanosynthesis; Lung cancer cells; Plasmodium parasites; Malaria
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Funding
- Department of Science and Technology, Science and Engineering Research Board (SERB), New Delhi, India [PDF/2016/000496]
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The development of effective and reliable drugs in the fight against malaria and cancer represents a crucial challenge in modern parasitology. The present investigation focuses on a simple and novel strategy for the biological synthesis of silver nanoparticles (Ag NPs) using beta-caryophyllene isolated from the leaf extract of Murraya koenigii, as reducing and stabilizing agent. UV-visible spectroscopy of the Ag NPs in aqueous suspension revealed strong surface plasmon resonance at 420 nm. Fourier transform infrared spectrum showed the various characteristic peaks of reducing functional groups. X-ray diffraction indicated 2 theta values confirming the Bragg's refraction index of Ag NPs. Scanning electron microscopy showed the nanoparticle spherical shapes while transmission electron microscopy showed nanoparticle sizes ranging from 5 to 100 nm, with an average size of 29.42 nm. Ag NPs exhibited promising activity on chloroquine-sensitive Plasmodium falciparum (3D7) (IC50: 2.34 +/- 0.07 mu g/ml), as well as significant cytotoxic activity on lung cancer cells (IC50: 9.39 +/- 0.08 mu g/ml). Overall, beta-caryophyllene synthesized Ag NPs could be further considered as a promising source for the development of cost effective and safer alternative drugs to treat malaria and cancer.
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