Journal
JOURNAL OF CLINICAL ULTRASOUND
Volume 45, Issue 8, Pages 480-487Publisher
WILEY
DOI: 10.1002/jcu.22471
Keywords
infantile hemangioma; ss-blocker; timolol; topical; pulsed wave Doppler ultrasound
Ask authors/readers for more resources
BackgroundTo assess the utility of color and spectral Doppler ultrasound at predicting infantile hemangioma (IH) response to timolol. MethodsEighty-three children (0-6 months old) with IH were treated with topical 0.5% timolol maleate twice daily for 6 months. They underwent color and spectral Doppler sonographic examinations at the first visit and 1 month after beginning timolol. Hemangioma volume, arterial diameter (AD), venous diameter (VD), resistance index (RI), pulsatility index (PI), peak arterial systolic velocity (PASV), maximum venous velocity, and mean venous velocity were measured. Therapeutic outcome was assessed at 6 months. ResultsThe hemangiomas were classified as deep (55.4%), hybrid (28.9%), or superficial (15.7%) and were located in the head and neck (36.1%), limbs (21.7%), or torso (42.2%). Regression occurred in 53 patients (63.9%). Timolol was the most effective in patients aged 5-6 months, in superficial hemangiomas, and in hemangiomas located on the torso. Receiver operating characteristic analysis revealed that changes in RI (sensitivity/specificity: 71.7%/96.7%), PI (sensitivity/specificity: 73.6%/86.7%), PASV (sensitivity/specificity: 81.1%/80.0%), change in arterial diameter (sensitivity/specificity: 58.5%/83.3%), and change in venous diameter (sensitivity/specificity: 62.3%/73.3%) at 1 month could predict response to timolol at 6 months. ConclusionsChanges in AD, VD, RI, PI, and PASV at 1 month could be used to predict response to timolol at 6 months. (c) 2017 Wiley Periodicals, Inc. J Clin Ultrasound45:480-487, 2017
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available