Journal
JOURNAL OF CLINICAL SLEEP MEDICINE
Volume 13, Issue 4, Pages 557-564Publisher
AMER ACAD SLEEP MEDICINE
DOI: 10.5664/jcsm.6542
Keywords
depression; kidney transplant recipients; REM sleep; slow wave sleep; stage 2 sleep
Categories
Ask authors/readers for more resources
Study Objectives: Both depression and sleep complaints are very prevalent among kidney transplant (kTx) recipients. However, details of the complex relationship between sleep and depression in this population are not well documented. Thus, we investigated the association between depressive symptoms and sleep macrostructure parameters among prevalent kTx recipients. Methods: Ninety-five kTx recipients participated in the study (54 males, mean +/- standard devation age 51 +/- 13 years, body mass index 26 +/- 4 kg/m(2), estimated glomerular filtration rate 53 +/- 19 ml/min/1.73 m(2)). Symptoms of depression were assessed by the Center for Epidemiologic Studies -Depression Scale (CES-D). After 1-night polysomnography each recording was visually scored and sleep macrostructure was analyzed. Results: The CES-D score was significantly associated with the amount of stage 2 sleep (r = 0.20, P < .05), rapid eye movement (REM) latency (r = 0.21, P < .05) and REM percentage (r = -0.24, P < .05), but not with the amount of slow wave sleep (r = -0.12, P > .05). In multivariable linear regression models the CES-D score was independently associated with the amount of stage 2 sleep (beta: 0.205; confidence interval: 0.001-0.409; P = .05) and REM latency (beta: 0.234; confidence interval: 0.001-0.468; P = .05) after adjustment for potential confounders. Conclusions: Depressive symptoms among kTx recipients are associated with increased amount of stage 2 sleep and prolonged REM latency. Further studies are needed to confirm our findings and understand potential clinical implications.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available