Journal
ORGANIC CHEMISTRY FRONTIERS
Volume 7, Issue 2, Pages 292-297Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9qo01272a
Keywords
-
Categories
Funding
- NSFC-Shandong Joint Fund for Marine Science Research Centers [U1606403]
- National Science and Technology Major Project for Significant New Drugs Development [2018ZX09735004]
- National Natural Science Foundation of China [81473337]
- National key Research and Development Program [2018YFC1706200]
- Scientific and Technological Innovation Project - Qingdao National Laboratory for Marine Science and Technology [2015ASKJ02-06]
Ask authors/readers for more resources
An efficient asymmetric multicatalytic system involving iminium catalysis and anion-binding catalysis has been developed, which exhibited high catalytic activity in a one-pot, two-step reaction sequence of 2-hydroxycinnamaldehydes and enolic 1,3-dicarbonyl nucleophiles to construct an enantioenriched 2,8-dioxabicyclo[3.3.1]nonane scaffold. The inherent phenolic hydroxyl group of 2-hydroxycinnamaldehyde played an important role in the catalytic process, which potentially provided a phenoxide anion to combine with the thiourea moiety of a bifunctional tertiary amine-thiourea catalyst via anion binding, thus making the developed multicatalytic system more economic and different from the previously reported catalytic mode.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available