Journal
ORGANIC CHEMISTRY FRONTIERS
Volume 7, Issue 2, Pages 223-254Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9qo01167f
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Funding
- National Natural Science Foundation of China [21772177, 21602202]
- Natural Science Foundation of Zhejiang Province [LY19B020016]
- Fundamental Research Funds of Zhejiang Sci-Tech University [2019Q065]
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The preparation of fluorine-containing compounds has attracted considerable attention due to the important applications of their related chemicals. Among the candidates, trifluoroacetimidoyl halides are considered as potent trifluoromethyl synthons to construct a wide variety of trifluoromethyl-containing compounds and trifluoromethyl-substituted N-heterocycles, which have found extensive applications in the fields of organic synthesis, pharmaceuticals, agrochemicals, and materials science. In the review, recent advances in the synthetic applications of trifluoroacetimidoyl halides are summarized. We specially focused on two different reaction modes upon trifluoroacetimidoyl halides, namely, coupling and annulation reactions to illustrate their synthetic applications and potentials in the construction of valuable trifluoromethyl-containing molecules. Their preparations were covered as well.
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