4.5 Article

Antisuicidal Response Following Ketamine Infusion Is Associated With Decreased Nighttime Wakefulness in Major Depressive Disorder and Bipolar Disorder

Journal

JOURNAL OF CLINICAL PSYCHIATRY
Volume 78, Issue 8, Pages 1068-1074

Publisher

PHYSICIANS POSTGRADUATE PRESS
DOI: 10.4088/JCP.15m10440

Keywords

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Funding

  1. National Institute of Mental Health (NIMH), National Institutes of Health (NIH) (IRP-NIMH-NIH) [NCT00024635, 04-M-0222]
  2. NARSAD
  3. Brain & Behavior Mood Disorders Research Award
  4. National Institutes of Health [K23MH093490]
  5. NATIONAL INSTITUTE OF MENTAL HEALTH [ZIAMH002857, K23MH093490, ZIAMH002927] Funding Source: NIH RePORTER

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Objective: Insomnia and disrupted sleep are associated with increased risk of suicide. The N-methyl-D-aspartate antagonist ketamine has been associated with reduced suicidal thoughts, but the mechanism of action is unknown. This study sought to evaluate differences in nocturnal wakefulness in depressed individuals who did and did not have an antisuicidal response to ketamine. Methods: Thirty-four participants with baseline suicidal ideation diagnosed with either DSM-IV major depressive disorder (n = 23) or bipolar depression (n = 11) between 2006 and 2013 completed nighttime electroencephalography (EEG) the night before and the night after a single ketamine infusion (0.5 mg/kg over 40 minutes). Suicidal ideation was assessed at baseline and the morning after ketamine infusion via several measures, including the Hamilton Depression Rating Scale suicide item, the suicide item of the Montgomery-Asberg Depression Rating Scale, and the first 5 items of the Scale for Suicide Ideation. A generalized linear mixed model evaluated differences in nocturnal wakefulness, as verified by EEG, between those who had an antisuicidal response to ketamine and those who did not, controlling for baseline nocturnal wakefulness. Results were also compared to the sleep of healthy controls (n = 22). Results: After analyses adjusted for baseline sleep, participants with an antisuicidal response to ketamine showed significantly reduced nocturnal wakefulness the night after ketamine infusion compared to those without an antisuicidal response (F-1,F-22 = 5.04, P = .04). Level of nocturnal wakefulness after antisuicidal response to ketamine did not differ significantly from nocturnal wakefulness in the control sample but did differ at a trend level (F1,40 = 3.15, P = .08). Conclusions: Reductions in wakefulness following ketamine may point to a biological mechanism underlying the effect of ketamine on suicidal ideation. (C) Copyright 2016 Physicians Postgraduate Press, Inc.

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