Journal
JOURNAL OF MOVEMENT DISORDERS
Volume 13, Issue 1, Pages 11-19Publisher
KOREAN MOVEMENT DISORDERS SOC
DOI: 10.14802/jmd.19057
Keywords
alpha-Synuclein; Immunotherapy; Tau proteins
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alpha-Synuclein and tau deposition in the central nervous system is responsible for various parkinsonian syndromes, including Parkinson's disease, multiple system atrophy, dementia with Lewy bodies, progressive supranuclear palsy and corticobasal degeneration. Emerging evidence has suggested that pathologic alpha-synuclein and tau are transmitted from cell to cell and further accelerate the aggregation of pathologic proteins in neighboring cells. Furthermore, extracellular pathologic proteins have also been reported to provoke inflammatory responses that lead to neurodegeneration. Therefore, immunotherapies targeting extracellular alpha-synuclein and tau have been proposed as potential disease-modifying strategies. In this review, we summarize completed phase I trials and ongoing phase II trials of immunotherapies against alpha-synuclein and tau and further discuss concerns and hurdles to overcome in the future.
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