Journal
CHEMICAL COMMUNICATIONS
Volume 56, Issue 7, Pages 1085-1088Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9cc08752d
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Funding
- National Institutes of Health [R01GM123508]
- National Science Foundation [DMR1454754]
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We report an elastase-responsive, H2S-releasing hydrogel prepared by covalently crosslinking a mixture of carboxymethylcellulose and poly(ethylene glycol) with an elastase-degradable peptide functionalized with an H2S-releasing S-aroylthiooxime (SATO) unit. Addition of elastase triggered a gel-to-sol transition, which exposed SATOs, leading to more and longer H2S release compared to untriggered gels.
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