Journal
CHEMICAL SCIENCE
Volume 11, Issue 3, Pages 742-747Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9sc05627k
Keywords
-
Categories
Funding
- National Key Research and Development Plan [2017YFA0505200]
- National Natural Science Foundation of China [21772110, 21822304]
Ask authors/readers for more resources
The first inverse hydroboration of pyridine with a diboron(4) compound and a proton source has been realized under simple basic and catalyst-free conditions. This process consists of a formal boryl anion addition to pyridine, which produces an N-boryl pyridyl anion complex, and the subsequent protonation of the anion complex. This process enables a simple and efficient method for the synthesis of multi-substituted N-H 1,4-dihydropyridine (1,4-DHP) derivatives that are difficult to prepare using established methods. Furthermore, this method allows for facile preparation of 4-deuterated 1,4-DHPs from an easily accessible deuterium ion source. This inverse hydroboration reaction represents a new mode for pyridine functionalization.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available