4.7 Article

The optimization of cancer photodynamic therapy by utilization of a pi-extended porphyrin-type photosensitizer in combination with MITO-Porter

Journal

CHEMICAL COMMUNICATIONS
Volume 56, Issue 7, Pages 1145-1148

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c9cc08563g

Keywords

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Funding

  1. Ministry of Education, Culture, Sports, Science and Technology [17H02094]
  2. Japanese Government (MEXT)
  3. Asahi Glass Foundation
  4. Dynamic Alliance for Open Innovation Bridging Human, Environment and Materials
  5. Indonesia Endowment Fund for Education (LPDP)
  6. Ministry of Finance of the Republic of Indonesia
  7. Ministry of Research, Technology, and Higher Education of the Republic of Indonesia
  8. [JP16H06280]

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The uncontrolled production of reactive oxygen species during photodynamic therapy (PDT) induces oxidative stress. The full potential of PDT is accomplished by delivery of a pi-extended porphyrin-type photosensitizer into mitochondria of tumor cells using a MITO-Porter, a mitochondrial targeting nanodevice. This strategy can be implemented for innovative cancer therapy.

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