Journal
JOURNAL OF MATERIALS CHEMISTRY B
Volume 8, Issue 3, Pages 438-446Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9tb02103e
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Funding
- National Natural Science Foundation of China [21671068]
- Guangdong Natural Science Foundation [2018B030315010]
- Hunan Key Research and Development Program [2019NCZDNY0005]
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Two novel Ru(ii) polypyridyl complexes bearing imidazo-phenanthroline conjugated hydroxybenzoic acid groups were designed to enhance the tumor targeting ability as photosensitizers for photodynamic therapy. [Ru(bpy)(2)(phcpip)] (ClO4)(2) (Ru-1) and [Ru(bpy)(2)(ohcpip)] (ClO4)(2) (Ru-2) (bpy = 2,2 '-bipyridine; phcpip = 2-(3-carboxyl-4-hydroxyphenyl) imidazo [4,5-f]phenanthroline; ohcpip = 2-(2-hydroxyl-3-carboxyphenyl) imidazo [4,5-f] [1,10] phenanthroline) were synthesized and their photodynamic antitumor activities were investigated. Both complexes displayed high photocytotoxicity toward cancerous cell lines HepG2, A549, MCF-7, and MDA-MB-231, but low photocytotoxicity toward normal cell lines GES-1 and Huvec. They were mainly localized at the nucleus of HepG2 cells after 24 h incubation, arrested the cell cycle at the G2/M phase and induced cancer cell apoptosis through reactive oxygen species (ROS) mediated pathways. Tumor targeting of the complexes is attributed to stronger molecular binding to DNA.
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