Journal
JOURNAL OF MATERIALS CHEMISTRY B
Volume 8, Issue 3, Pages 478-483Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9tb02120e
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Funding
- Shanghai Natural Science Foundation [18ZR1408300]
- National Natural Science Foundation of China [21574039, 21875063]
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Photodynamic therapy would suffer from low efficiency in the cancer treatment process if the reactive oxygen species (ROS) generated from a photosensitizer (PS) were reduced by intracellular glutathione (GSH). To overcome this limitation, in this work, we developed an amphiphilic branched copolymer with pendant vinyl groups, and it self-assembled with chlorin e6 (Ce6) into nanoparticles to fabricate a GSH-reaction response drug delivery system. The vinyl groups in the hydrophobic core of the nanoparticles were reacted with GSH by a thio-ene click reaction to release Ce6; simultaneously, the level of GSH decreased for enhanced PDT. Both in vitro and in vivo studies demonstrated that remarkable PDT efficacy for the nanosystem can be achieved.
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