Journal
NEW JOURNAL OF CHEMISTRY
Volume 44, Issue 3, Pages 884-891Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9nj04545g
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Funding
- Zhejiang Science and Technology Innovation Activity Plan (Newmiao Talents Program) for College Students [2019R406060]
- Fundamental Research Funds of Zhejiang Sci-Tech University [2019Y006]
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Silk fibroin (SF) from Bombyx mori is a natural macromolecule with remarkable biocompatibility and adhesive ability. For wound healing bio-adhesive applications, good biodegradability is essential. The ideal bio-adhesive is expected to be fixed together in the early stage of wound healing, adhere to tissues to avoid cracking, and present slow and favorable degradation at the wound site after healing. The residual adhesive component should be completely degraded after the wound has healed either through being absorbed by the body or excreted through the biological metabolism. Herein, SF was functionalized with dopamine through a one-step method with crosslinkers to enhance its adhesive ability. Poly(ethylene glycol) (PEG) was selected to optimize the gelation time (NESFB-Dopa). The ratio of SF and PEG, the ratio of crosslinker, the amount of dopamine and the adhesive environment were tuned to determine the optimal conditions. Following the ASTM standard, when the weight ratio of SF to PEG was 5 : 5, the molar ratio of NHS to EDC was 2 : 1, and the content of dopamine was 5 weight%; also, the tensile strength of NESFB-Dopa achieved greater values of 460.44 +/- 18.45 kPa and 503.32 +/- 16.54 kPa in dry and wet conditions, respectively, which demonstrated superior adhesive properties compared with those of the clinically used fibrin sealants.
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