Journal
ACS APPLIED BIO MATERIALS
Volume 3, Issue 2, Pages 891-901Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsabm.9b00970
Keywords
polytetrafluoroethylene (PTFE); chemical modification; chondroitin sulfate; endothelial cells; antithrombogenicity
Funding
- International Science & Technology Cooperation Program of China [2015DFA30550]
- 111 Project of Henan Province and Technology development plan of Henan Science, the techno l o g y departme [162102210159, 172102210489]
- Key Science & Technology Project for Institutions of Higher Education of Henan Province [19A430003]
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Polytetrafluoroethylene (PTFE) is one of the polymers extensively applied in biomedicine. However, the application of PTFE as a small-diameter vascular graft results in thrombosis and intimal hyperplasia because of the immune response. Therefore, improving the biocompatibility and anticoagulant properties of PTFE is a key to solving this problem. In this study, a hydroxyl group-rich surface was obtained by oxidizing a benzoin-reduced PTFE membrane. Then, chondroitin sulfate (CS), an anticoagulant, was grafted on the surface of the hydroxylated PTFE membrane using 3-aminopropyltriethoxysilane. The successful modification of the membrane in each step was demonstrated by Fourier transform infrared spectroscopy and X-ray photoelectron spectroscopy. Hydroxylation and the grafting of CS greatly increased the hydrophilicity and roughness of membrane samples. Moreover, the hydroxylated PTFE membrane enhanced the adhesion ability of endothelial cells, and the grafting of CS also promoted the proliferation of endothelial cells and decreased platelet adhesion. The results indicate that the PTFE membranes grafted with CS are able to facilitate rapid endothelialization and inhibit thrombus formation, which makes the proposed method outstanding for artificial blood vessel applications.
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