Journal
ACS APPLIED BIO MATERIALS
Volume 3, Issue 2, Pages 1283-1292Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsabm.9b01172
Keywords
selenium; aggregation-induced emission; cancer; radiotherapy; self-assembly
Funding
- National Basic Research Program of China [2018YFA0208900]
- China National Funds for Distinguished Young Scientists [21425416]
- National Natural Science Foundation of China [21734006]
- Funds for Creative Research Groups of China of the National Natural Science Foundation of China [21821001]
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Developing multifunctional carrier-free nanomedicine with high efficacy attracts tremendous attention in cancer treatment. Here, we develop selenium-containing carrier-free assemblies with aggregation-induced emission (AIE) property, which achieve the combination of cancer radiotherapy with chemotherapy. Under yradiation, diselenide bonds in the assemblies can be cleaved to form seleninic acid, which exhibits anticancer activity by upregulating the reactive oxygen species (ROS) levels in cancer cells. The incorporation of AIE groups further endows the selenium-containing assemblies with the ability of bioimaging. Their self-assembly behavior change under yradiation can be consequently observed in situ. The system combines cancer radiotherapy with chemotherapy, which exhibits improved anticancer activity.
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