Journal
JOURNAL OF CLINICAL MICROBIOLOGY
Volume 55, Issue 8, Pages 2304-2308Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JCM.00511-17
Keywords
antimicrobial activity; minimal inhibitory concentration; precision; susceptibility testing
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Funding
- Eunice Kennedy Shriver National Institute of Child Health and Human Development of the National Institutes of Health [T32HD055148]
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Antimicrobial susceptibility testing (AST) is a fundamental mission of the clinical microbiology laboratory. Reference AST methods are based on bacterial growth in antibiotic doubling dilution series, which means that any error in the reference method inherently represents at least a 2-fold difference. We describe the origins of current AST reference methodology, highlight the sources of AST variability, and propose ideas for improving AST predictive power.
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