Journal
CHEMICAL COMMUNICATIONS
Volume 56, Issue 8, Pages 1219-1222Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9cc06477j
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Funding
- National Natural Science Foundation of China [81872981]
- Program of Shanghai Academic/Technology Research Leader [18XD1403700]
- Youth Talent Sail Plan from the Shanghai Committee of Science and Technology [18YF1423600]
- Project of the Shanghai Municipal Commission of Health and Family Planning [2017YQ072, 201740152]
- development fund for Shanghai talents [2018105]
- Key project of Shanghai 3-year plan [ZY (2018-2020)-CCCX-2001-04]
- National Scientific and Technological Major Special Project of China [2019ZX09201004002]
- Shanghai Science and technology innovation project [17401901900]
- Xinglin Young Talent Program
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To monitor delicate changes of biological HOCl in vivo, a new probe (OH-substituted coumarin-hemicyanine, probe 2) was synthesized for NIR and ratiometric HOCl detection. Selectivity studies indicated that the electron-donating group (OH) substituted on the indolium moiety enhanced the selectivity to detect HOCl. With HOCl, the probe showed a ratiometric fluorescence (I-500/I-650) with a low detection limit (49.1 nM) and a rapid response (within 2 min). In addition, probe 2 was successfully applied to visualize exogenous and endogenous HOCl in living cells and animals and exhibited a perfect mitochondria target ability. This probe has been further studied as a potential and powerful tool to probe HOCl in arthritis models.
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